Postmortem redistribution of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH)
نویسندگان
چکیده
منابع مشابه
High-throughput toxicological analysis of Δ9-THC and 11-nor-9-carboxy-Δ9-THC by LC/MS/MS
A new high-throughput liquid chromatography / tandem mass spectrometry (LC-MS/MS) method for the quantification of Δ-tetrahydrocannabinol (THC) in suspect plant material and of its principal metabolite, 11-nor-9carboxy-Δ-tetrahydrocannabinol (THC-COOH), in human urine was developed and validated. The separation was performed on a Zorbax SB-C18 column under isocratic conditions using a mixture o...
متن کاملNew extraction method of THC and its metabolites, 11-OH-THC and THC-COOH, in plasma
Objectives: A liquid/liquid extraction technique on solid support of Δ9-tetradydrocannabinol (THC), 11-hydroxy-Δ9-tetradydrocannabinol (11-OH-THC) and 11-nor-Δ9-tetradydrocannabinol-9-carboxylic acid (THCCOOH) in plasma was developed in order to be assayed by high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS). Methods: The samples were extracted by liquid/liquid ex...
متن کاملUrinary excretion profiles of 11-nor-9-carboxy-D-tetrahydrocannabinol Study III. A D-THC-COOH to creatinine ratio study
Huestis and Cone reported in [J. Anal. Toxicol. 22 (1998) 445] that serial monitoring of D-THC-COOH/creatinine ratios in paired urine specimens collected at least 24 h apart could differentiate new drug use from residual D-THC-COOH excretion following acute marijuana use in a controlled setting. The best accuracy (85.4%) for predicting new marijuana use was for a D-THC-COOH/creatinine ratio 0.5...
متن کاملNovel automated extraction method for quantitative analysis of urinary 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH).
An automated extraction method for extracting the major urinary metabolite of cannabis, 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) was developed on the four-probe Gilson ASPEC XL4trade mark solid-phase extraction (SPE) system. The method works on liquid-liquid extraction principles but does not require the use of SPE cartridges. The limits of detection and quantitation an...
متن کاملEffects of oxidizing adulterants on detection of 11-nor-delta9-THC-9-carboxylic acid in urine.
Bleach, nitrite, chromate, and hydrogen peroxide-peroxidase are effective urine adulterants used by the illicit drug users to conceal marijuana-positive results. Methods for detecting nitrite and chromate are available. Effects of other oxidizing agents that could possibly be used as adulterants and are difficult to detect or measure are presented in this report. Urine samples containing 40 ng/...
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ژورنال
عنوان ژورنال: Forensic Science International
سال: 2011
ISSN: 0379-0738
DOI: 10.1016/j.forsciint.2011.06.028